Ah, I love comedy in games. First my favorite genre:
Maniac Mansion, Zak McKracken, Monkey Island 1 - 3, Day of the Tentacle, Sam & Max, Grim Fandango
Deponia 1 - 4, Edna & Harvey 1 + 2, The Book of Unwritten Tales 1 + 2,
Toonstruck, Space Quest series, Hector, The Inner World, The Journey Down
Ace Attorney series
Banjo-Kazooie/Tooie
Brütal Legend
Conker's Bad Fur Day
Daxter
Dead Rising series
Far Cry: Blood Dragon
GTA series
Lego City Undercover (and some other Lego games)
No One Lives Forever 1 + 2
Overlord 1 + 2
Portal 1 + 2
Psychonauts
Ratchet & Clank series
Sam & Max (Telltale series)
Shantae series
Tales from the Borderlands
Tales of Monkey Island
Uncharted series
You don't know Jack series
Oh, and of course South Park: The Stick of Truth... can't wait for The Fractured But Whole!
