Well, perhaps they could do a few regions along with a new one, if all of them aren't feasible. I just think it would be so freaking amazing to so Sinnoh, Unova, etc. in this HD, Open World setting. People would fap and climax just as hard if not harder than they did with Breath of the Wild.
But yeah, I do know it would take a lot of time and money, but if any franchise can afford it, it's Pokemon. :)
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