Many have said that Neo is too far along to change now, and I don't really doubt them. In my mind the impact this disparity will have depends primarily on how long the industry plans on supporting them:
For the first few years the gap will be very small in practice, relegated to resolution and slight performance differences much like today's multiplats but probably even harder to notice in front of you. However more powerful Scorpio may be, its games are still designed around the XBO, after all. If support ends along with the original XBO once 'XB2' arrives, the impact it made would be marginal.
However, if support doesn't end then and both Scorpio and Neo become the new baseline for game design, the gap will be more pronounced. I'm not quite convinced this will happen, though. Both systems sound rather unbalanced to me to become new design targets.
