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I'm still on my first playthrough, but I'm over 100 hours in, so I think I can safely say that overall, they're not worth it. I mean the kill monsters ones are fine because you want to do that anyway, but the rest I wouldn't go out of your way for. I have way, way, WAY, more money than I even know what to do with, most of the items they give can be obtained otherwise, and experience is more fun earned fighting monsters. For some reason I wound up completing every single side quest in the last town-like area of the game, and there were some nice rewards but nothing crucial.