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My predictions, in order of likelihood:

Xenoblade Chronicles X, Mario Tennis U, Mario & Luigi: Paper Jam footage/details
Twilight Princess HD revealed (guessing a February launch)
Indie reel/spotlight (Fast Racing NEO should be somewhere)
Virtual Console update
DLC updates for Smash/Mario Maker/Splatoon
Star Fox Zero/Fire Emblem: Fates/Bravely Second/Yokai Watch release dates
New eShop title to launch shortly after the Direct (possibly Project Guard?)
More Fire Emblem x SMT details
(Now we verge into the extremely unlikely territory)
Pikmin 4 announced
Zelda U footage
Mother 3 localised & launching on eShop that day

There's a lot they could pack in, really, even without many new announcements. Not to forget that there's also Project Treasure, Project Giant Robot and Pokken Tournament scheduled for Wii U in 2016, plus Metroid Prime: Federation Force for 3DS. As well as possible 3DS localisations like Monster Hunter X...