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Well... (I'll assume you mean published, and second parties and stuff)

Brain Training
Big Brain Academy
Drill Dozer
Chibi Robo
Golden Sun
Legend of Stafy (apparently Japan only)
Doshin the Giant
GiFTPIA (Again, Japan only)
Advance Wars (New to US)
Battalion Wars (only loosely related to Advance Wars)
Sin and Punishment (Japan Only)
Animal Crossing
Pikmin
Kururin (Japan Only)
Magical Vacation/Starsign
Rhythm Tengoku
Wario Ware (Wario's inclusion is tertiary)
DK King of Swing (You can discount if you want, but it is original enough)
Custom Robo
Trace Memory
Hotel Dusk
This weird Mecha game
Nintendogs
Band Brothers
Ouendan/EliteBeatAgents
Polarium
Electroplankton
True Swing Golf
Project Hacker (Japan)
Clubhouse Games
Card Hero (Japan)
Meteos (Published)
Touch Panic
Magnetica
Wii Sports
Excite Truck
Odama
Geist

And I'm probably missing the odd DS game or something.

That's a lot of new IP, all things considered. But it's easier to ignore it for the sake of saying Nintendo makes nothing new, right?