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If I were a betting man, I'd say Fallout 4 would be the most successful in sales and critic reviews. I don't know anything about the Xenoblade series, but that doesn't disqualifies me to say that due to Fallout's rabid fanbase on the three platforms, it will sell more both in launch and lifetime. On the sales aspect, it doesn't help that XCX is exclusive to the Wii U.