At first I thought it would be a chore to come up with a Top 5. But now I'm struggling to keep the list to go up from 5.
Mafia - When Sam says his last words on how Tommy's efforts to keep marked people alive were in vain.
The Last of Us - When Joel rescues Ellie from the hospital and kills all the fireflies. And then the ending...
Red Read Redemption - When John travels to south of the river on horseback.
Hitman Blood Money - When I get into The White House and Secret Invasion plays.
Uncharted 2 - The end of the train scene and when Elena gets badly hurt by the grenade.
Uncharted 3 - The entire cargo plane scene, when Nate gets thrown out the back, when he goes back in and somehow blows it up, and gets flung out of the plane again just to grab a parachute crate for his life, so he could see the big problem he was in. The music helped a lot.
Metal Gear Solid 4 - "This is good... isn't it?"
Pokemon Blue Version - The Final Road.
