UPDATE - Nintendo Begins Distributing Software Kit for New NX Platform

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Soundwave said:

$349.99 for console + portable together would not be bad IMO, remember this is basically like getting two Nintendo systems together.

Remember even the GameCube + GBA cost $300 at launch, that's roughly $400+ accounting for inflation.

If you bought the Wii U and 3DS, you likely paid $500 or more.

They could sell just the portable component seperately for people who just want that for cheaper. 

I'm more with 399.99.