I think it was King's Quest V where they abandoned the keyboard and went to a pointer only interface, where right clicking would toggle between different cursors (view, talk, take, walk to, and one for each inventory item). It was very well done in my opinion but it lost the magic of ambiguous commands that Sierra gracefully handled with "I don't know what a cheeseburger is" or their quirky humor for something perverted.
Still I wouldn't mind to see a game like that brought back though I'd much rather try new iterations, they could be so darn challenging sometimes, and sometimes you'd be thinking about it away from the game coming up with ideas about whether this would work with that.
Zack & Wiki was similar to a point and click adventure except broken up into small manageable levels.
