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Most Windows games of the last 15 years run fine. A few don't run on 64-bit-systems but most will. Windows 10 doesn't support some old disc protections like SECUROM, so these games need a crack or you buy the digital version (Steam, GOG) for a few bucks.

Almost all MS-DOS-games (1980 - 1997) run fine with DOS-Box, many of the best games from 1980 - 2000 (point&click adventures) run even better with ScummVM.

Most games with Windows95/98-focus (1995 - 2000) will be problematic, especially on 64-bit-systems. But GOG.com has already fixed many of them.