Hmm
A new Kirby platformer, a new or remade Fire Emblem, a new Retro game, a new Kid Icarus, a new Zelda, a new Smash Bros, a new Bayonetta, a new Shin Megami Tensei spin off title or main game, a new No More Heroes, a new Fighting game from Capcom or SNK(P) or Arc Systems (That doesn't suck), a new Metriod, a new F-Zero, a new Sin and Punishment game and/or a remake of one of the Mother/Earthbound games.
Edit: Also a new Mega Man X/Legend game or remake.