It really depends on when it releases and what it is. If anything I'm fairly certain there's going to be a 3D Mario at release regardless.
I'm thinking, from the top of my head:
Launch Titles:
3D Mario
Zelda U NX port if 2016; Zelda TP HD if 2017
New IP by EAD
Launch Window:
Mario Kart 9
Retro Studios game (could be new IP as well, I'm not seeing them doing a Metroid or DK anymore)
Animal Crossing







