OK, here's my update:
Just got back to Sarif Industries after the first boss fight. I'm playing complete stealth and pacifist specialising in melee and stun gun. Leading up to this point:
- Got the Old school gamer achievement again (I didn't do this the last time I played the DC, but got it on the original game)
- Let Zeke go and saved everyone at the plant
- Hacked into everyone's office at Sarif and got access to the storage room by the helipad
- Completed the quest for Jenny Alexander with all the evidence, getting into DRB without being seen and capturing the gangsters and final bad guy; all non-lethal of course!
- Completed the quest for Megan's mother but kept the bracelet (there's an achievement for this before anyone thinks me heartless 
)
- Took the totally empathetic route for the Sanders questline
- This is the first time I'm playing with the CASIE mod this early. It's had its uses and such as getting into the police station, but not as useful as I thought it might be. I seemed to have pissed Haas off which hasn't happened in my previous playthroughs, but he still let me in. I'll be interested to see if this has an effect later on.
Boss fight:
I actually had a lot of fun with this. The Director's Cut versions are just a lot better than in the original. Even on the hardest difficulty, they're lots of alternative routes. Not perfect, but a lot better than they were. First, I used a couple of concussion grenades and fired off a few headshots with the Revolver, before running to the second floor via a ladder. I hacked the terminal to open the locked door. Sneaked my way to the now open door, broke into the office and hacked another terminal to activate a couple of turrets, then placed them at flanking point and let them finish him off!
Will update more after a few more chapters.
