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For RPGs, I thought Mass Effect was a good game, but definitely enjoyed my second playthrough more.

For other games... No More Heroes I thought was going to be a poor to average game based on the first 10 minutes, I warmed to it a little after the first boss fight, thought it was ok after the 2nd boss fight. It continued to grow on me through to the end to the point that I immediately started a second playthrough.

I can't think of any other games I have enjoyed significantly more second time around.