Retro Studios should be Nintendo's Naughty Dog: Journey to the West

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That's Metroid's role. Metroid Prime Trilogy feels more like a western game. To do an Uncharted game, just make the Prime games in third person view, greater complex overworlds and try to find a balance between the solitary Primes 1 and 2, and the Full of crew stories in Prime 3 and Other M.

If you believe Metroid is too niche, them something similar to Metroid and Mass Effect will work.