If it's a handheld, a new generation Pokemon would be best to create worldwide buzz, though Gamefreak wouldn't put it on an entirely new system I think.
That wouldn't be my personal preference, not by a long shot. In the perfect world it'd be a Zelda game, which would ensure me to get the system day 1. Otherwise I'd be more than happy with a 3D Mario, which I'm always happy with.







