Square07 on 21 April 2008
| No. | SYS | TITLE | PUB | REL | First Week Sales | Source |
| 1 | X360 | HALO 3 | Microsoft | 9 / 2007 | 2,700,000 | PR & Vgchartz |
| 2 | XB | HALO 2 | Microsoft | 11 / 2004 | 2,380,000 | PR |
| 3 | PS2 | Grand Theft Auto: San Andreas | Rockstar | 10 / 2004 | 2,053,983 | NPD |
| 4 | Wii | Super Smash Bros. Brawl | Nintendo | 3 / 2008 | 1,420,000 | PR & Vgchartz |
| 5 | PS2 | Grand Theft Auto: Vice City | Rockstar | 10 / 2002 | 1,412,429 | NPD |
| 6 | GB | Pokemon Gold / Silver | Nintendo | 10 / 2000 | 1,400,000 | PR |
| 7 | PS2 | Madden NFL 06 | EA | 8 / 2005 | 1,170,000 | PR |
| 8 | PS2 | Madden NFL 07 | EA | 8 / 2006 | 1,012,790 | NPD |
| 9 | NDS | Pokemon Diamond / Pearl | Nintendo | 4 / 2007 | 1,000,000 | PR |
| 10 | PS2 | Madden NFL 2004 | EA | 8 / 2003 | 850,000 | Vgchartz proj. |
| 11 | PS2 | Madden NFL 2005 | EA | 8 / 2004 | 810,000 | Vgchartz proj. |
| 12 | X360 | Call of Duty 4 | Activision | 11 / 2007 | 733,000 | Vgchartz proj. |
| 13 | XB | Madden NFL 06 | EA | 8 / 2005 | 683,000 | comp’d w/ PS2 ver. |
| 14 | X360 | Madden NFL 08 | EA | 8 / 2007 | 666,000 | Vgchartz proj. |
| 15 | GBA | Pokemon Ruby / Sapphire | Nintendo | 3 / 2003 | 663,000 | guestimate |
| 16 | N64 | Zelda: Ocarina of Time | Nintendo | 11 / 1998 | 641,072 | NPD |
| 17 | N64 | Pokemon Stadium | Nintendo | 3 / 2000 | 632,000 | guestimate |
| 18 | PS2 | Gran Turismo 4 | Sony | 2 / 2005 | 618,559 | NPD |
| 19 | PS2 | Kingdom Hearts II | Square-Enix | 3 / 2006 | 614,436 | NPD |
| 20 | GB | Pokemon Yellow | Nintendo | 10 / 1999 | 600,000 | PR |
| 21 | GBA | Pokemon Fire Red / Leaf Green | Nintendo | 9 / 2004 | 596,000 | guestimate |
| 22 | GC | Zelda: The Wind Waker | Nintendo | 3 / 2003 | 588,000 | guestimate & PR? |
| 23 | PS2 | Madden NFL 2003 | EA | 8 / 2002 | 580,000 | Guestimate |
| 24 | X360 | Madden NFL 07 | EA | 8 / 2006 | 570,463 | NPD |
| 25 | X360 | Assassin’s Creed | Ubisoft | 11 / 2008 | 563,000 | Vgchartz proj. |
| 26 | GEN | Mortal Kombat | Acclaim | 9 / 1993 | 550,000 | guestimate |
| 27 | Wii | Super Mario Galaxy | Nintendo | 11 / 2008 | 540,000 | PR & vgchartz proj. |
| 28 | PS2 | Final Fantasy XII | Square-Enix | 11 / 2006 | 533,000 | Vgchartz proj. |
| 29 | PS2 | God of War II | Sony | 3 / 2007 | 517,000 | Vgchartz proj. |
| 30 | X360 | Gears of War | Microsoft | 11 / 2006 | 491,000 | Vgchartz proj. |
| 31 | PS2 | Madden NFL 08 | EA | 8 / 2007 | 469,000 | Vgchartz proj. |
| 32 | X360 | Guitar Hero III | RedOctane | 10 / 2007 | 433,000 | Vgchartz proj |
| 33 | PS2 | Final Fantasy X | Squaresoft | 12 / 2001 | 423,000 | guestimate |
| 34 | Wii | Zelda: Twilight Princess | Nintendo | 11 / 2006 | 411,862 | NPD |
"The next time someone tells you Compact Discs are the wave of the future, tell them the future doesn't belong to snails!" - Nintendo Power, April 1994
