It depends really. It's normally animals that get me, I just know that the griffin creature in The Last Guardian is going to die, and seeing it in the trailer coupled with that music... Ah shite. It'll get me.
Zelda from Skyward Sword. It was the only time I've actually genuinely liked her character enough to focus on the story with her rather than side quests.
Losing Agro in Shadow of the Colossus was hellish as well. Fuck Wander, just make sure the horse is alright.







