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Uncharted- Set the standard for big budget games and is responsible for inspiring many other games including the rebirth of Tomb Raider, Last of us, The Order, Star Wars 1313 and many other games.

COD- Set the standard for twitch shooting on consoles.

Mass Effect- Set the standard intertwining the decision making process overa trilogy of games. Also set the standard for TPS/ARPG hybrids.

Assassins Creed- Set the standard alternative open world after Grand Theft Auto.

The Walking Dead- Set the standard for story driven choice based experiences

Honorable mention: Gears of War (much like Uncharted) for influencing many games with its coverbased mechanics.