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It has to be the Elder scrolls games. They can just go on forever, especially once you start modding them.

Oblivion: 430+ hours
Skyrim: 310+ hours
Morrowind: 100+ hours

I also play most Bioware and CDProjekt games multiple times.

In terms of pure single play through campaign/story mode though:

Dragon Age Origins 60+ hours to complete
Dragon Age: Inquisition 80+ hours to complete
Final Fantasy VIII 100+ hours to complete (I made sure to do everything before the final boss)