My "wild" predictions are that Final Fantasy Chrystal Chronicles will be an online game, it will integrate with the DS version of the game and will be the sleeper hit of the show; Nintendo will show off three completely unconventional games which will make everyone in the audience question their appeal (two of these games will go on to sell millions of copies worldwide); and a Lucasarts starwars lightsaber game will be displayed which seems very interesting but has many flaws at the early stage of development (it will show up again at E3 2008 looking far more polished and entertaining).
Beyond that I would say that Disaster: Day of Crysis will surprise people at how high of quality it is; I say this because Nintendo buying the company reminds me of how Nintendo bought Retro prior to them releasing Metroid Prime.
