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Most influential exclusives, imo:
-Halo CE (brought online multiplayer on consoles)
-GTA 3 ( created a new standard for open world games - was initially a Ps2 exclusive)
- Brain Training (was the first game to demonstrare the mass market appeal of touch screen games)
-Resident Evil 4 (created new standards for 3rd person action games, that later evolved in 3rd person shooters)