I think first person games can benefit from this where the outline of the game screen's border changes dynamically to certain situations. Top-down or isometric perspective can benefit from this as well with the game screen's border shaped just like the area of a room/overworld. Combined that with 3D and it can produce a hologram like display.
One thing the 3DS' 3D screen lacks is the the screen has to share space with a speaker and a camera. If I can play a game with good 3D effects like Super Mario 3D Land with a top screen that is entirely a screen, the 3D effect could make the levels pop out like a hologram.







