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Mummelmann said:

Hint for 45:

This game, along with a much more famous and monolithic title, was spawned on what could be considered the most unlikely platform for the genre and the controller on this system made things like free-aiming a thing on consoles. This game sports some highly original enemies that had not been portrayed in this genre before, and which were popularized four years prior by one of the highest grossing movies of the 90's.

Dino Crisis.