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Lets be straight here. RE4 defined a generation, everything done in RE4 was new or very hard to do at the time. TLOU is great in its own ways but it didn't offer anything new to the gaming world, it was just a well made game. RE4 at the time with the Hardware limitations was completely mind blowing where as TLOU wasn't exactly the best looking game of its generation and it also had the help of next gen hardware to achieve its great story telling. RE4 was more of a game and still today is mind blowing in every way, So is TLOU but ill give me votes to the game that defined a generation, and that's RE4.