Resident Evil 4 Vs The Last of Us.

[*Sound Of Rain]

The Last Of Us was a much better game to me.

Although, for me, the older RE games are all miles better than RE4 so I don't like RE4 much to begin with.

To answer your other questions that everyone else is ignoring:

Leon would beat Joel quite easily
Ada would also kick the crap out of Tess
However, Ellie would beat the dog shit out of Ashley...