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Chris Hu said:
Its pretty save to say that nobody that is currently playing quarterback in the NFL will pass Peyton Mannings TD numbers.
http://sports.yahoo.com/news/a-look-at-peyton-manning-s-record-run-to-500-tds-and-beyond-221421193.html

It's probably also highly unlikely that anyone else currently playing in the NFL will get to 500 TD thrown.

Maybe not, but Blake Bortles has a shot at 500 interceptions if given a chance.