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Yakuza 4's final boss. Every final boss ends on some sort of rooftop in the Yakuza series. On Yakuza 4, you have four characters, and between the dialogue and bosses themselves, the battles in Yakuza 4 are my favorite.

Honorable mentions.

Lords of Shadow 2 Victor Belmont, Aria of Sorrow Julius Belmont, and Symphony of the Night Richter Belmont. The battles aren't very difficult, but the Belmont battles are my favorite in the Castlevania franchise. Richter Belmont on Portait of Ruin isn't included because the way the AI is designed in that battle, really doesn't feel that exciting of a battle.

Every other last boss in the Yakuza series. The rest of the final bosses in Yakuza are almost as good as that of Yakuza 4. Yakuza 3's last boss is better than every last boss on Yakuza 4, but the combined four on Yakuza 4 is what gives them the edge over Yakuza 3's last boss.

Every boss from Shadow of the Colossus,

Vergil from DMC3 and DmC Devil May Cry.