I think Okami will have a similar following and sales pattern of Zack and Wiki. It will garner decent enough sales (esp. for this inexpensive port) but probably not enough for a sequel for a game of its size and scope. (Z&W will get another installment in the next 6-18 months.)
Break even is probably around 100K. Expected sales around 200-250K. Could reach 500K lifetime worldwide with strong word or mouth and additional support by the community and Nintendo. Going against it is the fact that it's a bit pricey ($40 versus Z&W's $30) and has a terrible launch date in between two Nintendo blockbusters (Brawl and Kart).
Numbers are like people. Torture them enough and you can get them to say anything you want.
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