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NesFe said:

If you have PS+ you can upload your saves to the cloud using the yellow plus sign next to the manual to upload saves. I don't think you can upload save data to PC. However, you can use Content manager to back up your entire vita to PC and then restore to a new memory card which will keep all your data/games/saves etc...

You don't have to make a complete backup to save your savegames on a PC.

When you "copy content" to or from the PC, you can select individual games to transfer. All Vita save games, patches and licenses are automatically transfered together with the main program, each in separate subfolders:

Only the save games of PS1 and PSP games have to be transfered seperately from the main program.