One thing is certain, Mario and Pokémon for sure will take home this generation too.
Even if MS/Rare released an awesome sequel to Banjo it would not sell as much as any of the "main" Mario platformers, even if it was better. So Mario will take that genre, again and again. And all the platformers from Sony, Sly, Ratchet, Crash etc. won't either, no matter how good or bad they might be.
For adventure sequels to Zelda and Uncharted will absolutely be on the top. If something else will pop up I am not sure, but those games will absolutely hold the top place.
For racing we will see GT and Mario Kart again. Forza I am not sure how much it sells, but it's also on the top. Those three games this generation again is my bet.
For the other genres I don't really know. Shooters like COD and BF will continue to sell a whole lot, but we might see some other big names come too. Destiny maybe. Halo also sells a whole lot. But my bet is that COD will "win". And fighters I know almost nothing about, but I suppose SSB.








