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All great games mentioned so far. I'm going to go with something different:

Joust - One of my favorite arcade games. No sequel, but it is getting a movie adaptation so maybe there will be movie based Joust game.

Tron - Okay there was a Tron 2 with was totally different but cool. But definately a dead franchise.

Dewy's Adventure - Yeah, it had sickeningly sweet presentation, but I loved the gameplay, slightly flawed as it was. But poor sales for the first will kill the franchise right off the bat. Too bad.

Okami - What? Why wasn't this mentioned already?

Myst - Okay, Myst was hardly cut short, but it is dead. Love to see it resurrected on Wii.