The Last of Us...such an easy choice for me. It is everything I could ever want from a game. The story affectd me more than FFX's even and that is huge to me. So so HUGE!!!
My top 5 this generation:
1) The Last of Us
2) Grand Theft Auto V
3) Uncharted 2
4) Metal Gear Solid 4
5). Assassins Creed IV
Honourable mention: NFS Hot Pursuit as I put in the most hours in that game...more than any game ever, in fact!