Here's my $0.02 ...
In the next generation on of the key issues that Nintendo (and all developers) will face is increasing development costs due to the quantity and quality of 3D graphical assets that they will have to produce. What I believe Nintendo should invest in is the creation of several (probably between 4 and 8) 3D asset "factories" (studios of 200+ artists that only create artistic assets) in developing nations (like China, India, Mexico, and Brazil) in order to produce a massive library of objects and textures that we see in the real world. When this library is complete the licencing of the objects within the library should be free for games produced exclusively for their next generation platform.
To further explain what I am refering to, imagine if Nintendo created a library of objects that included (pretty much) every peice of furniture that you could buy, a library of textures that included every wallpaper, rug, or material you see on a daily basis. Also imagine if this library included human avatars which could be customized and also had a massive wardrobe of readily designed clothes.
When a developer was faced with what could be hundreds of millions of dollars of game-ready content that they can use for free I suspect that they would be very willing to produce exclusive games; at the same time, the fact that many developers could complete games with very little need to produce additional content would allow even small developers to produce very fleshed out games.
