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1. Nano Technology with the ability to regenerate limbs and cure most diseases if not all of them.
2. Further advancements in space technology maybe a moon base or artificial gravity.
3. Faster than light technology.
4. Fossil Fuels no longer being Humanities primary source of energy.
5. Humanity to discover a space faring civilization.
Almost none of this is likely to happen in my lifetime except maybe Nano Technology which I hear is 30 years out and maybe, MAYBE a moon base.