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Final-Fan said:
^ Maybe you're thinking of playing Gamecube games. Every time you start up a Gamecube game, you need to use the Wii remote to start the game, then switch to the GC controller to play the GC game.

I think he's thinking of games that require you to resync your remotes when you start them.  This isn't an issue for single player games, but some multiplayer games are retarded about this.