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I am left-handed, but use my right hand for some tasks. I remember when I got my Wii and began to play Twilight Princess, it was difficult in the begining to aim with the right hand, but I got used to it quickly. When I play Wii games where you only need to use Wiimote without nunchuk, I always use my left hand though ;)

The only game I ever had a problem with was Kid Icarus Uprising, luckily it had support for Circle Pad Pro. But even then it feels weird, and I cannot control the stylus or write anything with my right.

Also when I'm on a PC, I always use the mouse with my right hand.



Yep.