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I've always felt like what really separates anime and cartoon is how the story is treated.

Example: Spongebob I feel safe to say is a cartoon
Avatar: The Last Airbender I do not.

Hunter x Hunter I feel safe to say is an anime
Gintama I do not

Most cartoons also use different means of expressing their emotions. Anime use more symbolic expressions while cartoons use more literal ones, it seems.