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I was one who'd never played Mass Effect before and started with Mass Effect 3 for Wii U, which was the first game I bought after Nintendo Land. I really enjoyed it. The backstory comic book thing filled in a lot of the holes (and anything else that confused me, I simply looked up)

I really enjoyed it a lot. I will say that it's the only Wii U game I've had that I've since sold, just because as amazing and immersive as that game was, I just don't see me playing Mass Effect 3 again unless it's to continue a game I started from Mass Effect and Mass Effect 2 (No idea how I'd go about playing those as I don't have PS3 or 360... maybe get the computer version?)