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I really wouldn't care if alcohol and tobacco became illegal. Alcohol has played a contributing factor in countless violent and/or sexual crimes--not to mention accidents--and tobacco is basically the leading cause of death in first world countries. The world would be better off without them.

I accept marijuana for medicinal purposes; I'm pretty much all for any substance provided that it measurably improves a patient's condition. However, I am opposed to self-medicating with mind-altering substances, and the recreational use of this drug has a demonstratively adverse effect on neurological function and development. I'm fine with it remaining illegal for recreational use.