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Chris Hu said:

Simple clue left handed people are better in using their left hand and controller layout makes a difference to most left handed people I'm pretty sure of that. 

I'm left-handed and I've never had any issues with the left stick of the Dualshock. Right stick, that's another story, but that's just because generally it's used for things that require more precise movements and stick generally aren't very good for that. Either way, I've had no stick placement issues with any of the Dualshock controllers so far.