Reasons why Samus should not be in Mario Kart
1) Samus with the Speed Booster runs roughly 5 times faster than even 150cc karts.
2) Samus has a gun and doesn't need items at all.
3) Samus is slightly genocidal...
4) Since Samus has a gun and is slightly genocidal, every time she shot a character, that character would die. I don't just mean "F-Zero/will not finish the race" die but rather "a grey tombstone now appears in character selection where that character used to be" die. By the end of a single Grand Prix, every character except Samus would be dead inlcuding the floating Lakitu who made the mistake of trying to tell Samus which direction she should be going.
5) If all the other characters are dead, little Timmy will cry. That will annoy Samus and then little Timmy will meet an unfortunate end.
As you can see from these points above, putting Samus in Mario Kart would not only be a bad idea but a very dangerous one.