Looney Tunes, argument over. The historical impact of that alone in animation trumps anything out of Japan then or now.
Flintstones, Jetsons, He-Man, The Simpsons, Family Guy, GIJoe, Transformers, all the various Looney Tunes characters (Bugs Bunny, Tweety, Daffy Duck, Elmer Fudd, Porky Pig) Tiny Toons Adventures, Tom and Jerry, Teenage Mutant Ninja Turtles, Ghostbusters, Micky Mouse, Popeye, Betty Boop, X-Men, Spider-Man, Superman, Batman Animated Series, Pirates of Dark Water, Droopy, Scooby Doo, Felix the Cat, Woody Woodpecker, Inspector Gadget, Yogi Bear, Ren and Stimpy, Smurfs, Jonny Quest, Donald Duck, Wacky Races, Ducktales, Gargoyles, Chip and Dale, Winnie the Pooh, Thundercats, Spongebob, Garfield, Aqua Teen Hunger Force, King of the Hill, Beavis and Butthead, South Park. Damn, that's just a a primer, how influential are all these cartoons.
Not to mention Disney animated movies from Snow White up to Lion King!
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