I used to not care for the 3D because most games just had really crappy 3D, but I did test the 3D just to see how it was with each game I played. Lords of Shadow Mirror of Fate's 3D was jaw dropping so the second time I played through it, other than when underwater, I played with the 3D on.
SMT4 also has really good 3D, but the problem on the game is that you'll go back and forth to your menu, you'll sometimes look at the bottom screen to look at the map, etc. So games where you're frequently switching back and forth from top to bottom, you really don't want to use the 3D effect because it's disorienting and that's when it really hurts your eyes.
So, so far, Lords of Shadow Mirror of Fate is the only one really worth using the effect. Everything else, even SMT4 with it's really good 3D effect, not worth it.







