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wait wasn't Clair and Jill protagonists in RE? A similarly violent kinda shindig that sold. Mass Effect (and a whole lot of WRPG's), Heavy Rain had Maddison, Lightning ofcourse was a shared protagonist with everyone but actually marketed with her. There's a lot of games with shared playable female protagonists that sell.

Games with Sole female Protagonists I can think of off the top of my head push the issue more because you can't market it with a guy. Sole to me would matter more for proving the point. Rather than sidekick or shared protagonist.

Longest Journey (April Ryan and didn't sell that well because its an adventure game).
Tomb Raider (Partly doesn't count because of her overt boobiness, new one counts for sure)
Metroid (Kinda doesn't really count because she wasn't really marketed as a girl, except for in Other M, but that's good in some ways because she is a girl, and not marketed as a girl)
No One Lives Forever
Remember Me (didn't sell)
Heavenly Sword (Kinda Sold, but not exactly BUT HAD ANNA TORV FROM FRINGE!)

I'm just making a list for people to ignore