Five minutes into The Last of Us and I've already shed a tear. (spoilers)

[S.T.A.G.E.]

Majora said:
I cried with Ni No Kuni twice. Once for sadness and the other because it was just so beautifully done that by the end I was elated but sad that the adventure was over. What a game.

I had a tear during Ni No Kuni as well. Such an underrated game.