I think this was already discussed, but here is my prediction. Note, I don't remember what I said last time:
Controller: It will be a massive evolution from the Wii Remote. So advanced and innovative that I can't imagine how could it be.
CPU and GPU: Nintendo and ATi will develop a custom GPGPU, solely for their next console. It's gonna be cheap, small and cool, at less than 22nm. Probably a Multi-Core design in it. All games will be in HD plus the mandatory SD, just in case.
RAM and storage: Will feature a unified memory architecture, using at least 4GB of GDDR6 RAM. It will use a SSHDD, but it will not be that big. Blu-ray? Don't think so.
Overall performance will be at around 4x of the PS3, that means something like a current top-end PC, but in a much smaller package
In the 'others' department, it's gonna feature a massively improved online service, much more intuitive and easier. Probably gonna feature some kind of downloadable media service, aside from the usual game stuff. Mandatory WiFi, Bluetooth, BC, and etc.'s. No physical media movie playback.
It's gonna sell for $250.
