Assassin's Creed, after you've completed the first section in Damascus and you realise that that's the game. Rinse and repeat.
Metal Gear Solid 3. The CQC actions were buggy as hell and never worked. Near the end I realised that I'd used the wrong button. >_< Because reading the manual is too much work.
Star Fox Adventures. Not the game's fault (I think...) but my memory card hated it and corrupted my save file two times. Got really good at it though!
Zelda: Spirit Tracks. Ice skating and evil trains can go to hell.
Star Wars (NES). I hate, hate, hate the death star. Big labyrinth where you need to take leaps of faith (that damage you!!! Bastards!!!) to progress. Rooms filled with spikes and gravity thingies that sends you all over the place.
