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CGI-Quality said:

Bleh, two Titans for the Fall. Can't ignore 6GB of VRAM.

Is this for gaming or your other rendering stuff?

I don't know about your rendering needs but in terms of gaming you won't need more than 3 GB before the GTX 800 series comes out and you upgrade to those...

Because of efficiency, different GPUs use different amounts of VRAM.  2GB 680 uses 20% less VRAM on average than a GTX 580 for most games. I bet the GK110 is even more efficient than GK104 cards. So I doubt you'll need more than 3GB for a while... Unless you want to do 3 X 4K res in surround or something crazy like that.